• Protective effect of glutathione and selenium against alloxan induced lipid peroxidation and loss of antioxidant enzymes in erythrocytes

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    • Keywords

       

      Lipid peroxidation; superoxide dismutase; catalase; glutathione peroxidase; alloxan

    • Abstract

       

      Alloxan is a diabetogenic drug and is known to induce diabetes through generation of free radicals. The toxic oxygen species can be detoxified by antioxidant enzyme system and thus reduce the deleterious effect of lipid peroxidation. Erythrocytes exposed to alloxan induced lipid peroxidationin vivo as well asin vitro. Although alloxan treatment produced a deleterious effect on antioxidant enzymes, pretreatment with glutathione and selenium led to a recovery of the activities of superoxide dismutase and glutathione peroxidase. However, catalase activity increased on alloxan treatment. Alloxan reduced blood glucose level significantly within 60 min but thereafter a slow and steady rise was observed.

    • Author Affiliations

       

      Poonam Yadav1 S Sarkar1 D Bhatnagar1

      1. School of Biochemistry, D A University, Indore - 452001, lndia
    • Dates

       
  • Journal of Biosciences | News

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