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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/018/02/0207-0212

    • Keywords

       

      Phospholipids; cAMP; mycobacteria; forskolin

    • Abstract

       

      Forskolin, an adenylate cyclase activator and a cyclic AMP analogue, dibutyryl cyclic AMP have been used to examine the relationship between intracellular levels of cyclic AMP and lipid synthesis inMycobacterium smegmatis. Total phospholipid content was found to be increased in forskolin grown cells as a result of increased cyclic AMP levels caused by activation of adenylate cyclase. Increased phospholipid content was supported by increased [14C] acetate incorporation as well as increased activity of glycerol-3-phosphate acyltransferase. Pretreatment of cells with dibutyryl cyclic AMP had similar effects on lipid synthesis. Taking all these observations together it is suggested that lipid synthesis is being controlled by cyclic AMP in mycobacteria.

    • Author Affiliations

       

      Monica Sareen1 Harpinder Kaur1 G K Khuller1

      1. Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012, India
    • Dates

       
  • Journal of Biosciences | News

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