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    • Keywords


      Amphotericin-B; antileishmanial activity; renal toxicity; liposomes; tissue distribution; drug delivery

    • Abstract


      Antileishmanial activity and organ distribution of the antifungal drug Amphotericin-B in free and liposomised form have been studied in Balb/c mice infected withLeishmania donovani. Results indicate that Amphotericin-B in the liposomised form is significantly more active than the free form. This increase in the activity is perhaps related to the reduced drug toxicity rather than the altered drug distribution at the site of infection.

    • Author Affiliations


      Imran Ahmad1 2 Anshu Agarwal1 Ajay Pal1 3 P Y Guru1 3 B K Bachhawat1 2 C M Gupta1

      1. Division of Membrane Biology, Central Drug Research Institute, Lucknow - 226 001, India
      2. Liposome Research Centre, University of Delhi, South Campus, Benito Juarez Road, New Delhi - 110 021, India
      3. Division of Parasitology, Central Drug Research Institute, Lucknow - 226 001, India
    • Dates

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