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    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/016/04/0217-0221

    • Keywords

       

      Amphotericin-B; antileishmanial activity; renal toxicity; liposomes; tissue distribution; drug delivery

    • Abstract

       

      Antileishmanial activity and organ distribution of the antifungal drug Amphotericin-B in free and liposomised form have been studied in Balb/c mice infected withLeishmania donovani. Results indicate that Amphotericin-B in the liposomised form is significantly more active than the free form. This increase in the activity is perhaps related to the reduced drug toxicity rather than the altered drug distribution at the site of infection.

    • Author Affiliations

       

      Imran Ahmad1 2 Anshu Agarwal1 Ajay Pal1 3 P Y Guru1 3 B K Bachhawat1 2 C M Gupta1

      1. Division of Membrane Biology, Central Drug Research Institute, Lucknow - 226 001, India
      2. Liposome Research Centre, University of Delhi, South Campus, Benito Juarez Road, New Delhi - 110 021, India
      3. Division of Parasitology, Central Drug Research Institute, Lucknow - 226 001, India

    • Dates

       
      Published
      December 1991
      Manuscript received
      15 November 1990
      Manuscript revised
      29 April 1991

  • Journal of Biosciences | News

      Forthcoming Special issue.


    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

      Posted on April 12, 2023
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    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

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