• Chloroquine delivery to erythrocytes inPlasmodium berghei-infected mice using antibody-bearing liposomes as drug vehicles

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      https://www.ias.ac.in/article/fulltext/jbsc/016/03/0137-0144

    • Keywords

       

      Drug targeting; liposomes; antibody; erythrocyte; malaria; drug-resistant infection; mice

    • Abstract

       

      Suitability of anti-erythrocyte F(ab’)2-bearing liposomes as vehicles for chloroquine in the treatment of chloroquine resistantPlasmodium berghei infections in mice has been examined. Free chloroquine or chloroquine encapsulated in antibody-free liposomes failed to show much effect on the resistant infections, but the same doses of this drug after being encapsulated in antibody-bearing liposomes exhibited a significant inhibitory effect on this infection. These results indicate that chloroquine delivery in antibody targeted liposomes may help in the successful treatment of the chloroquine resistant malarial infections.

    • Author Affiliations

       

      Subhash Chandra1 Ajay K Agrawal1 C M Gupta1

      1. Divisions of Membrane Biology and Parasitology, Central Drug Research Institute, Lucknow - 226 001, India
    • Dates

       
  • Journal of Biosciences | News

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