• Chloroquine delivery to erythrocytes inPlasmodium berghei-infected mice using antibody-bearing liposomes as drug vehicles

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    • Keywords


      Drug targeting; liposomes; antibody; erythrocyte; malaria; drug-resistant infection; mice

    • Abstract


      Suitability of anti-erythrocyte F(ab’)2-bearing liposomes as vehicles for chloroquine in the treatment of chloroquine resistantPlasmodium berghei infections in mice has been examined. Free chloroquine or chloroquine encapsulated in antibody-free liposomes failed to show much effect on the resistant infections, but the same doses of this drug after being encapsulated in antibody-bearing liposomes exhibited a significant inhibitory effect on this infection. These results indicate that chloroquine delivery in antibody targeted liposomes may help in the successful treatment of the chloroquine resistant malarial infections.

    • Author Affiliations


      Subhash Chandra1 Ajay K Agrawal1 C M Gupta1

      1. Divisions of Membrane Biology and Parasitology, Central Drug Research Institute, Lucknow - 226 001, India
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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