• Phosphoenolpyruvate-succinate-glyoxylate pathway in the filarial parasiteSetaria digitata

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      https://www.ias.ac.in/article/fulltext/jbsc/016/03/0121-0126

    • Keywords

       

      Filariae; Setaria digitata ; mitochondriae; tricarboxylate cycle; phosphoenol-pyruvate-succinate pathway; glyoxylate cycle

    • Abstract

       

      Setaria digitata, a filarial parasite of cattle possesses certain unique characteristics like cyanide insensitivity, and lack of cytochromes. In the present study, we have shown that the parasite has an incomplete tricarboxylic acid cycle with the absence of activities of isocitrate dehydrogenase, α-ketoglutarate dehydrogenase and succinyl-CoA synthase. However the parasite showed the existence of glyoxylate cycle and phosphoenolpyruvate-succinate pathway. The widely used antifilarial drug diethylcarbamazine caused general inhibition of all enzymes of phosphoenolpyruvate-succinate pathway and glyoxylate cycle except that of fumarase and isocitrate lyase. The results may pave the way for new targets for chemotherapy in the control of filarial parasites.

    • Author Affiliations

       

      M Mohamed Rafi1 R Kaleysa Raj1

      1. Department of Biochemistry, University of Kerala, Kariavattom, Trivandrum - 695 581, India
    • Dates

       
  • Journal of Biosciences | News

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