• Conformation of azidothymidine: an anti-AIDS drug

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/016/01-02/0029-0042

    • Keywords

       

      Anti-AIDS drug; azidothymidine; conformation; PCILO; nucleoside antibiotic

    • Abstract

       

      The nucleoside antibiotic, 3′-azido-3′-deoxythymidine, or simply, azidothymidine has shown great promise in inhibiting the human immuno deficiency virus and in reducing mortality among AIDS patients. Conformational properties of azidothymidine have been investigated by quantum-mechanical PCILO method and compared with those of the parent nucleoside, thymidine. The results indicate great similarity between them and this similarity is remarkably striking in the situations that prevail in aqueous solution. This result has important biological significance in explaining the drug action of azidothymidine.

    • Author Affiliations

       

      Anil Saran1 R P Ojha1 2

      1. Chemical Physics Group, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Bombay - 400 005, India
      2. Physics Department, Gorakhpur University, Gorakhpur - 273 009, India
    • Dates

       
  • Journal of Biosciences | News

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