• Activities of myelin bound cytidine 5′-diphosphate-choline 1, 2 diacyl-glycerol choline phosphotransferase and uridine 5′-diphosphate-galactose-ceramide galactosyltransferase under restricted food intake

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    • Keywords


      Myelin; UDP-galactose-ceramide galactosyltransferase; CDP-choline; nutritional stress

    • Abstract


      Activities of cytidine 5′-diphosphate-choline glycerol choline phosphotransferase and uridine 5′-diphosphate galactose-ceramide galactosyltransferase were determined in isolated myelin in different brain regions of control, and rats with restricted food intake. Kinetic experiments indicated an increase inKm value of phosphocholinetransferase in brain stem of undernourished rats, without significant change in the specific activity of this enzyme. Stimulation of this myelin bound enzyme activity was also evident in the animals when myelin was treated with the detergent: Tween CF. 54. Though specific activities of galactosyl transferase in myelin of undernourished rats were significantly diminished, theKm of this enzyme was unaltered. These studies point to an adverse effect of early nutritional stress on the activities of enzymes bound to myelin membrane which has hitherto been considered metabolically inert.

    • Author Affiliations


      S Padmini1 P Srinivasarao

      1. National Institute of Nutrition, Hyderabad - 500 007, India
    • Dates

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