-
- Home
- Journals
- Journal of Biosciences
- Volume 15
- Issue 3
-
Polyvanadate acts at the level of plasma membranes through α-adrenergic receptor and affects cellular calcium distribution and some oxidation activities
T Ramasarma Sharada Gullapalli Vidya Shivaswamy C K Ramakrishna Kurup
Volume 15 Issue 3 September 1990 pp 205-210
-
-
Fulltext
Click here to view fulltext PDF
Permanent link:
https://www.ias.ac.in/article/fulltext/jbsc/015/03/0205-0210 -
Keywords
Polyvanadate ;α-adrenergic receptor ;calcium ;oxidation -
Abstract
The activities of calcium-stimulated respiration, calcium uptake, α-glycero-phosphate dehydrogenase and rates of oxidation in state 3 and of H2O2 generation, were found to increase and that of pyruvate dehydrogenase decrease in mitochondria isolated from livers of rats administered intraperitoneally or perfused with polyvanadate. Phenoxybenzamine, an antagonist of α-adrenergic receptor, effectively prevented these changes. It was also found that perfusion of the liver with polyvanadate reproduced one of the best characterized events of α-adrenergic activation-stimulation of protein kinase C in plasma membrane accompanied by its decrease in cytosol. These experiments indicate for the first time the α-adrenergic mimetic action of polyvanadate.
-
Author Affiliations
T Ramasarma1 Sharada Gullapalli1 Vidya Shivaswamy1 C K Ramakrishna Kurup1
- Department of Biochemistry, Indian Institute of Science, Bangalore - 560 012, India
-
Dates
- Published
- September 1990
-
-
Journal of Biosciences
Volume 48, 2023
All articles
Continuous Article Publishing mode
-
Journal of Biosciences | News
-
To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".
Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.
Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.
Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx
Posted on April 12, 2023< -
Editorial Note on Continuous Article Publication
Posted on July 25, 2019Click here for Editorial Note on CAP Mode
Forthcoming Special issue.
-