• Inhibition of anion transport in the red blood cell membrane by anionic and non-anionic arginine-specific reagents

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    • Keywords


      Red blood cell; anion transporter; arginine-specific reagents

    • Abstract


      Arginine specific reagents are found to be powerful inhibitors of anion exchange in the red blood cell membrane. Some of these inhibitors such as cyclohexandione, phenylglyoxal and 2, 3-butandione are found to produce their inhibition by interacting covalently with band 3. In contrast to the action of these compounds, the inhibition caused by the phenylglyoxal derivative 4-hydroxy-3-nitrophenyl-glyoxal has been found to be completly reversible. In extending the studies on the mode of action of these compounds on sulfate exchange and to get some more information about their binding site, the degree of inhibition caused by different phenylglyoxal derivatives which have a similar core but differ in their substituent groups have been compared. The interaction between the binding sites of these compounds and other anion transport inhibitors have also been studied.

    • Author Affiliations


      Laila Zaki1

      1. Max-Planck-Institut für Biophysik, Heinrich-Hoffmann-Stra Βe 7, Frankfurt am Main 71 - 6000, FRG
    • Dates

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