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Nuclear magnetic resonance and thermal studies of drug doped dipalmitoyl phosphatidyl choline-H2O systems
K Usha Deniz P S Parvathanathan Geeta Datta C L Khetrapal K V Ramanathan N Suryaprakash S Raghotama
Volume 15 Issue 3 September 1990 pp 117-123
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https://www.ias.ac.in/article/fulltext/jbsc/015/03/0117-0123 -
Keywords
Dipalmitoyl phosphatidyl choline ;drug-membrane interaction ;differential scanning calorimetry ;1 H NMR ;31P NMR -
Abstract
The influence of the sulfone drugs, diamino diphenyl sulfone and diamino monophenyl sulfone on the phase transitions and dynamics of dipalmitoyl phosphatidyl choline-H2O/D2O vesicles have been investigated using differential scanning calorimetry and nuclear magnetic resonance. Our results show that diamino diphenyl sulfone interacts quite strongly with the headgroups of dipalmitoyl phosphatidyl choline whereas the diamino monophenyl sulfone-dipalmitoyl phosphatidyl choline interaction is quite weak. This is attributed to the difference in the structure and hydrophobic character of the two drugs.
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Author Affiliations
K Usha Deniz1 P S Parvathanathan1 Geeta Datta2 C L Khetrapal3 K V Ramanathan3 N Suryaprakash3 S Raghotama3
- Nuclear Physics Division, Bhabha Atomic Research Centre, Trombay, Bombay - 400 085, India
- Biochemistry Division, Bhabha Atomic Research Centre, Trombay, Bombay - 400 085, India
- Sophisticated Instrument Facility, Indian Institute of Science, Bangalore - 560 012, India
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Dates
- Published
- September 1990
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Journal of Biosciences
Volume 48, 2023
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Journal of Biosciences | News
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To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".
Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.
Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.
Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx
Posted on April 12, 2023< -
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Posted on July 25, 2019Click here for Editorial Note on CAP Mode
Forthcoming Special issue.
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