• Effects of postnatal treatment with naloxone on plasma gonadotropin, prolactin, testosterone and testicular functions in male rats

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    • Keywords


      Opioid peptides; pituitary; plasma hormone levels; naloxone; neonatal rats

    • Abstract


      Opioid peptides are implicated in the control of gonadotropin and prolactin secretion. The role of opioid antagonist naloxone and its effects on plasma gonadotropin, prolactin, testosterone levels and testicular hyaluronidase, acid phosphatase, [3H]uridine and thymidine incorporation, RNA, DNA and protein concentrations were evaluated in rats after administration of naloxone beginning day 1 through 21 and autopsied on 45, 60 and 90 days of age. Plasma gonadotropin and testosterone levels were significantly elevated after naloxone treatment. Testicular hyaluronidase and acid phosphatase activity increased till 60 days post treatment and declined thereafter. Concentrations of RNA and protein did not change significantly but the concentration of DNA declined at 45 and 60 days of age. These results suggest that endogenous opioid peptides exert regulatory influence on gonadotropin secretion which in turn control the testicular function in the male rat.

    • Author Affiliations


      P Anandalaxmi1 E Vijayan1 2

      1. School of Life Sciences, University of Hyderabad, Hyderabad - 500 134, India
      2. School of Life Sciences, Pondicherry University, Pondicherry - 605 104, India
    • Dates

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