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Protein deficiency and age related alterations in rat peritoneal macrophage lipids
Volume 14 Issue 4 December 1989 pp 367-377
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Permanent link:
https://www.ias.ac.in/article/fulltext/jbsc/014/04/0367-0377 -
Keywords
Protein deficiency ;peritoneal macrophages ;lipids ;cholesterol/phospholipid ratio ;fatty acid composition -
Abstract
The effects of dietary protein restriction and age on the thioglycollate elicited peritoneal macrophage lipid constituents were studied. Impact of subtle changes in lipid components on macrophage functions have been assessed. Lipid profiles of macrophages recovered from rats fed 20 and 4% protein diets and stock diet fed rats (0 and 3 wk) were comparable qualitatively. Quantitative analysis however revealed significant decrease in phospholipids (30–40%) and consequent elevation of cholesterol/phospholipid molar ratios in the protein depleted and young rats (0 wk), compared to the protein fed groups. The protein deficient and the young rats also exhibited accumulation of certain neutral lipids and reduction in triglycerides. Analysis of fatty acid methyl esters of macrophage phospholipids revealed the predominance of long chain polyunsaturated fatty acids even when oleic (C18:1) and linoleic (C18:2) formed the bulk of unsaturated fatty acids in the diet. However, the long chain poly unsaturated fatty acid content, particularly the docosahexaenoic acid (C22:6n-3) was greatly reduced in the protein depleted and 0 wk rats. Observed changes in the long chain polyunsaturated fatty acids of macrophage phospholipids may be of physiological significance as they modulate the immunological functions of the cell.
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Author Affiliations
- Food Technology and Enzyme Engineering Division, Bhabha Atomic Research Centre, Trombay, Bombay - 400 085, India
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Dates
- Published
- December 1989
- Manuscript received
- 24 April 1989
- Manuscript revised
- 19 August 1989
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Journal of Biosciences
Volume 48, 2023
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Journal of Biosciences | News
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To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".
Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.
Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.
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