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    • Altered kinetic properties of rat heart mitochondrial enzymes following experimental-thyrotoxicosis

      B N Dave F R Billimoria S S Katyare

      Volume 14 Issue 4 December 1989 pp 341-349

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/014/04/0341-0349

    • Keywords

       

      Thyrotoxicosis; Arrhenius kinetics; ATPase, succinate oxidase

    • Abstract

       

      Effects of T3- and T4-induced thyrotoxicosis on temperature-dependent Arrhenius kinetics of succinate oxidase and Mg2+- and Mg2+ + 2,4-dinitrophenol-dependent ATPase activities in rat heart mitochondria were examined, For succinate oxidase system, treatment with T3 and T4 caused increase in the energy of activation in high temperature range in a dose-dependent manner. For low temperature range, increase in energy of activation was apparent only with higher doses of the hormones; with low doses a small but reproducible decrease was evinced. The phase transition temperature decreased significantly under these conditions. For the Mg2+- and Mg2++2,4-dintro-phenol-dependent-ATPase activities, the activation energy values in high temperature range decreased in general. Activation energy values in low temperature range recorded a generalized increase in the Mg2+-ATPase enzyme system while the value did not change significantly for the Mg2+ + 2,4-dinitrophenol-ATPase; phase transition temperature registered a small but reproducible decrease under these conditions. The results are suggestive of increased membrane fluidization possibly through increased proportion of unsaturated fatty acids. The differential effects seen for succinate oxidase and ATPase systems are consistent with different lipid protein domains of these enzyme systems.

    • Author Affiliations

       

      B N Dave1 F R Billimoria1 S S Katyare1 2 3

      1. Department of Biochemistry, L. T. M. Medical College and L. T. M. G. Hospital, Sion, Bombay - 400 022, India
      2. Biochemistry Division, Bhabha Atomic Research Centre, Trombay, Bombay - 400 085, India
      3. Department of Biochemistry, Faculty of Science, M. S. University of Baroda, Baroda - 390 002, India

    • Dates

       
      Published
      December 1989
      Manuscript received
      26 October 1988
      Manuscript revised
      7 August 1989

  • Journal of Biosciences | News

      Forthcoming Special issue.


    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

      Posted on April 12, 2023
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