1. Home
    2. Journals
    3. Journal of Biosciences
    4. Volume 14
    5. Issue 4

    • Effect of experimentally induced thyrotoxicosis on oxidative energy metabolism in rat heart mitochondria

      S S Katyare F R Billimoria

      Volume 14 Issue 4 December 1989 pp 329-339

    • Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/014/04/0329-0339

    • Keywords

       

      Thyrotoxicosis; heart mitochondria; energy metabolism

    • Abstract

       

      Treatment of rats with T3 resulted in a significant decrease in body weight, while the heart weight increased. T4 treatment had less marked effect on body weights but resulted in decreased heart weights. Serum T4 levels decreased significantly with simultaneous increase of T3 level following T3 treatment, whereas with T4 treatment, levels of both T4 and T3 increased in the serum. Low doses of T3 (0.5 µg ) caused decrease in mitochondrial protein content while high dose of T4 (1 µg), caused significant increase in mitochondrial mass. The state 3 respiration rates were significantly depressed following T3 and T4 treatments, in a substrate specific manner with the effects being more pronounced with T3; these responses with T4 were dose-dependent for succinate and ascorbate + N,N,N′,N′-tetramethyl-p-phenylenedíamme. State 4 respiration rates also exhibited similar corresponding changes. ADP/O ratios were not changed but ADP-phosphorylation rates were decreased significantly particularly so with the T3-treated animals. Treatment with T3 also resulted in lowering of intramitochondrial cytochrome contents. Similar effects were seen also with higher doses of T4. The results thus indicate that T3- and T4- thyrotoxicosis results in impaired energy metabolism in heart mitochondria.

    • Author Affiliations

       

      S S Katyare1 2 F R Billimoria1 3

      1. Biochemistry Division, Bhabha Atomic Research Centre, Trombay, Bombay - 400 085, India
      2. Department of Biochemistry, Faculty of Science, M. S. University of of Baroda, Baroda - 390 002, India
      3. Department of Biochemistry, L. T. M. Medical College and L. T. M. G. Hospital, Sion, Bombay - 400 022, India

    • Dates

       
      Published
      December 1989
      Manuscript received
      26 October 1988
      Manuscript revised
      7 August 1989

  • Journal of Biosciences | News

      Forthcoming Special issue.


    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

      Posted on April 12, 2023
      <

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2022-2023 Indian Academy of Sciences, Bengaluru.

Contact | Site index