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    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/013/03/0249-0256

    • Keywords

       

      Cardiac hypertrophy; nick translation of intact nuclei; DNase I digestion pattern; myosin heavy chain genes

    • Abstract

       

      Nick translation of intact rat heart nuclei has shown that the incorporation of [3H]-dATP is greater in hypertrophic heart nuclei than in normal heart nuclei suggesting that hypertrophic heart nuclei have more DNase I sensitive regions than normal heart nuclei. DNase I sensitivity analysis has shown that the rate and extent of digestion of myosin heavy chain genes are greater in hypertrophic than in normal heart nuclei. Dot blot hybridization analysis of myosin heavy chain transcripts from hypertrophic heart nuclei using myosin heavy chain cDNA as probe has shown that the sensitivity of myosin heavy chain genes to DNase I in hypertrophic heart nuclei correlates with myosin heavy chain gene activation and increased number of transcripts.

    • Author Affiliations

       

      N Selvamurugan1 J Kamala1 C Rajamanickam1

      1. Department of Biochemistry School of Biological Sciences, Madurai Kamaraj University, Madurai - 625 021, India

    • Dates

       
      Published
      September 1988
      Manuscript received
      10 July 1987
      Manuscript revised
      12 March 1988
      Final version published online
      1 September 1988

  • Journal of Biosciences | News

      Forthcoming Special issue.


    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

      Posted on April 12, 2023
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    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

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