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    • Keywords


      Ergosterol; cholesterol; phospholipids; fatty acids; amino acids; transport; Microsporum gypseum

    • Abstract


      Ergosterol and cholesterol supplementation resulted in a significant increase (1·5-fold) in the sterol content while phospholipid remained unaffected inMicrosporum gypseum. The levels of phosphatidylethanolamine and phosphatidylcholine increased in ergosterol supplemented cells. However, a decrease in phosphatidylcholine and an increase in phosphatidylethanolamine was observed in cholesterol grown cells. The ratio of unsaturated to saturated fatty acids decreased on ergosterol/cholesterol supplementation. The uptake of amino acids (lysine, glycine and aspartic acid) decreased in sterol supplemented cells. Studies with fluorescent probe l-anilinonaphthalene-8-sulfonate showed structural changes in membrane organisation as evident by increased number of binding sites in such cells.

    • Author Affiliations


      Seema Vaidya1 Geeta Bharti1 Rakesh Pandey1 G K Khuller1

      1. Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012, India
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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