• Effect of luteinizing hormone releasing hormone analogues on testosterone metabolismin vitro — A study with mature rat ventral prostates

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    • Keywords


      Prostate; LHRH analogues; testosterone metabolism; 5 α-reductase activity

    • Abstract


      The effects of two luteinizing hormone releasing hormone analogues (a superagonist and an antagonist) on the conversion of testosterone to dihydrotestosterone in homogenates prepared from adult rat ventral prostates were studied. At higher doses, the superagonist showed a significant dose-dependent inhibition of the conversion of testosterone to dihydrotestosterone. In comparison, the antagonist showed only a marginally inhibitory trend. The implications of these observed effects vis-a-vis the use of the analogues in the endocrine management of prostatic cancer have been discussed.

    • Author Affiliations


      A Maitra1 R Joseph1 A R Sheth1 N A Sheth1 2 J Joseph1 3

      1. Institute for Research in Reproduction, Jahangir Merwanji Street, Parel, Bombay - 400 012, India
      2. Cancer Research Institute, Parel, Bombay - 400 012, India
      3. Magyar Tudomanyos Akademia, Hungarian Academy of Sciences, 1361 Budapest, V1 Roosevelt Ter 9, Budapest, Hungary
    • Dates

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