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Interaction energy studies on pyrazolopyrimidine nucleoside antibiotics — A theoretical study: Oxoformycin B
Rajendra Prasad Ojha M Roychoudhury Nitish K Sanyal
Volume 12 Issue 3 September 1987 pp 311-320
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https://www.ias.ac.in/article/fulltext/jbsc/012/03/0311-0320 -
Keywords
Interaction energy ;nucleoside analogues ;transcription ;incorporation ;inhibition -
Abstract
The biological activity of oxoformycin B has been exafned on the basis of the model developed for the incorporation of nucleoside analogues during transcription. Claverie’s simplified formula has been employed for intermolecular interaction energy calculation. The pairing energy of oxoformycin B base with complementary bases as well as the association energy with nucleic acid base pairs have been calculated. The results are compared with those of similar computation with normal bases. In addition to the in-plane interaction the vertical interaction energy between the analogue and the normal bases has been computed to specify the particular position of the analogue in the chain. On the basis of the model an attempt has been made to explain the mechanism of the biological action of oxoformycin B and to compare the biological activity of pyrazolopyrimidine nucleoside analogues.
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Author Affiliations
Rajendra Prasad Ojha1 M Roychoudhury1 Nitish K Sanyal1
- Department of Physics, University of Gorakhpur, Gorakhpur - 273 009, India
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Dates
- Published
- September 1987
- Manuscript received
- 26 May 1986
- Manuscript revised
- 10 June 1987
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Journal of Biosciences
Volume 48, 2023
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Journal of Biosciences | News
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To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".
Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.
Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.
Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx
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