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    • Keywords


      Lectin receptor; ganglioside; accessibility; distribution in membrane

    • Abstract


      To examine how surface Potential controls the reactivity of glycoconjugates at cell surface, the interaction of galactose-sPecific lectinse.g. peanut agglutinin,Ricinus cummunis agglutinin with liPosomes bearing asialo GM1 were studied in the Presence of varying amount of ganglioside mixture, GMn. The Presence of 5% GMn causes comPlete slowing down of PreciPitin reaction and thereby make carbohydrate moiety of asialo GM1 comPletely inaccessiblei.e. ‘cryPtic’. In contrast the Presence of 1–2% GMn enhances the aPParent rate and amPlitude of the PreciPitin reaction as surface Potential becomes more negative. The relevance of the findings has been discussed in relation to the exPression and involvement of the cell-surface sialic acid residues during develoPment and differentiation.

    • Author Affiliations


      S K Podder1 A Chakraborti1 K Vijayalakshmi1 P Lalit Kumar Singh1

      1. Department of Biochemistry, Indian Institute of Science, Bangalore - 560 012, India
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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