1. Home
    2. Journals
    3. Journal of Biosciences
    4. Volume 11
    5. Issue 1-4

    • Spectroscopic studies on the interaction of bilirubin with symmetrical alkyl diamines

      Kasturi Lahiri Puranam P Balaram

      Volume 11 Issue 1-4 March 1987 pp 485-493

    • Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/011/01-04/0485-0493

    • Keywords

       

      Bilirubin conformations; bilirubin-amine interactions; difference spectroscopy; fluorescence

    • Abstract

       

      The interactions of symmetrical alkyldiamines with bilirubin-IX α have been examined in dichloromethane and dioxane solutions, by visible region difference sPectroscoPy and florescence methods. In dioxane solutions a clear difference is observed between the comPlexes of the shorter chain diamines (number of sPacer methylene grouPs (n ≤4) ) and the longer chain diamines (n ≥6) . The variations in sPectral features with diamine chain length are less Pronounced in dichloromethane. The sPectroscoPic results are consistent with the occurrence of distinct bilirubin conformations dePending uPon the solvent and the geometry of the interacting recePtor. Based on molecular modelling two conformations are ProPosed. A ‘ridge-tile’ model similar to that observed in crystals is favoured for binding to the longer diamines, while a ‘quasi-cyclic’ structure is Preferred for interaction with the short chain diamines.

    • Author Affiliations

       

      Kasturi Lahiri Puranam1 P Balaram1

      1. Molecular BioPhysics Unit, Indian Institute of Science, Bangalore - 560 012, India

    • Dates

       
      Published
      March 1987

  • Journal of Biosciences | News

      Forthcoming Special issue.


    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

      Posted on April 12, 2023
      <

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2023-2024 Indian Academy of Sciences, Bengaluru.

Contact | Site index