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    • Structural organization of cholera toxin gene and its expression in an environmental non-pathogenic strain ofVibrio cholerae

      Uma Bhattacharyya Amit Ghosh Ranajit K Ghosh

      Volume 11 Issue 1-4 March 1987 pp 231-238

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/011/01-04/0231-0238

    • Keywords

       

      Vibrio cholerae ; avirulent strain; toxin gene

    • Abstract

       

      Non-pathogenic, environmental strain ofVibrio cholerae, ELTOR Ogawa EW6 carries a copy of the cholera toxin gene in its chromosome. Restriction enzyme digestion followed by Southern blot analysis revealed that the structure of the cholera toxin gene in this organism is different from that found in the virulent strains. The xbaI site which has been found to be conserved in the cholera toxin of the virulent strains examined so far, is absent here. Results of the RNA dot blot analysis indicated that the cholera toxin gene in EW6 is transcribed much less efficiently compared to the cholera toxin gene present in the virulent strainVibrio cholerae classical Inaba 569B.

    • Author Affiliations

       

      Uma Bhattacharyya1 2 Amit Ghosh1 Ranajit K Ghosh1

      1. Indian Institute of Chemical Biology, Jadavpur, Calcutta - 700 032, India
      2. Department of Biochemistry, University of North Carolina, Chapel Hill, North Carolina - 27514, USA

    • Dates

       
      Published
      March 1987

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    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


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