Autoregulation of therho gene insures a controlled level of a critical gene product independent of cellular changes. We have investigated the autoregulation ofrho, the gene that encodes the transcription termination factor,rho. In a DNA dependentin vitro coupled transcription-translation system,rho represses its own synthesis, confirming the autoregulatory nature ofrho. srho is believed to perform its negative regulatory role by modulating transcription termination at an early site in the operon.
Volume 46, 2021
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