• Study of Salmonella endotoxin on the changes in lipid-protein interactions of membranes using Arrhenius plots of cetylcholinesterase as a tool

    • Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/011/01-04/0081-0087

    • Keywords

       

      Membrane; acetylcholinesterase endotoxin; transition temperature; inhibition

    • Abstract

       

      Lipopolysaccharides ofSalmonella typhimurium inhibit the activity of acetylcholinesterasein vitro in both synaptosomal and erythrocyte membranes. Arrhenius plots show that the transition temperatures of membrane bound acetylcholinesterase are significantly reduced in the presence of lipopolysaccharides, and the activation energies above and below transition temperature have increased with the lowering of transition temperature. These results indicate that an alteration in the fluidity of the phospholipid layer of the membranes, may be responsible for the membrane-specific effect of lipopoly-saccharides on acetylcholinesterase activity.

    • Author Affiliations

       

      M K Ray1 A Mitra1 B Mukherjee1 G C Chatterjee1

      1. Department of Biochemistry, University College of Science, 35, Ballygunge Circular Road, Calcutta - 700 019, India
    • Dates

       
  • Journal of Biosciences | News

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2021-2022 Indian Academy of Sciences, Bengaluru.