• How does cobalamin (vitamin B12) enter and traverse mammalian cells?

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    • Keywords


      Cobalamin; uptake; cells; receptor; endocytosis; acidic vesicles

    • Abstract


      This overview is intended to present recent information available on the work done in understanding the mode of entry of cobalamin into and out of mammalian cells. I have focused primarily on the uptake of cobalamin bound to 3 proteins: intrinsic factor, transcobalamin II and R-proteins. Even though the nature of these cobalamin binding proteins, and the receptors involved in the internalization of these proteins is known, a total picture on the intracellular trafficking of cobalamin and the binding proteins is far from complete.

    • Author Affiliations


      Bellur Seetharam1

      1. Department of Medicine, Division of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri - 63110, USA
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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