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    • Keywords


      Protective immunity; BCG; oral immunisation,Mycobacterium tuberculosis H37Rv; Mycobacterium avium intracellulare

    • Abstract


      The relative protective efficacy of oral administration of mycobacteria as compared to the conventional intradermal route of vaccination has been assessed in guinea pigs. Skin test reactivity to partially purified protein derivative and protective immunity to challenge with virulentMycobacterium tuberculosis were used as parameters of protective immunity.

      Oral immunisation of guinea pigs either with BCG or withMycobacterium avium intracellulare induces skin test reactivity and protective immunity comparable to that induced by intradermal route of vaccination. Oral exposure ofMycobacterium avium intracellulare prior to oral or intradermal dose of BCG did not interfere with the protective immunity induced by BCG in guinea pigs challenged withMycobacterium tuberculosis H37Rv.

    • Author Affiliations


      Sujatha Narayanan1 C N Paramasivan1 R Prabhakar1 P R Narayanan1

      1. Tuberculosis Research Centre, Spurtank Road, Chetput, Madras - 600 031, India
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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