Prevention of aortic lesions and hyperlipidaemia by alfalfa seed extract in cholesterol fed rabbit
V P Dixit S C Joshi Prabha Jain
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Extract of alfalfa seed (ethanolic 50 % v/v) prevents the development of plaque formation and hyperlipidaemia in cholesterol fed rabbits. It inhibits the elevation of serum total cholesterol, triglycerides, phospholipids, LDL-cholesterol and total cholesterol/phospholipid ratio, while HDL-cholesterol/total cholesterol ratio increases, which is associated with a reduced incidence of atherosclerosis. Further reduction in total cholesterol and phospholipid contents of liver and heart muscle are suggestive of a beneficial role of the seed extract. The possible mechanisms of action are discussed.
V P Dixit1 S C Joshi1 Prabha Jain1
Volume 48, 2023
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