• Prevention of aortic lesions and hyperlipidaemia by alfalfa seed extract in cholesterol fed rabbit

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    • Keywords


      Alfalfa seed extract (ethanolic 50% v/v); HDL-cholesterol; atherosclerosis; hyperlipidaemia; LDL-cholesterol

    • Abstract


      Extract of alfalfa seed (ethanolic 50 % v/v) prevents the development of plaque formation and hyperlipidaemia in cholesterol fed rabbits. It inhibits the elevation of serum total cholesterol, triglycerides, phospholipids, LDL-cholesterol and total cholesterol/phospholipid ratio, while HDL-cholesterol/total cholesterol ratio increases, which is associated with a reduced incidence of atherosclerosis. Further reduction in total cholesterol and phospholipid contents of liver and heart muscle are suggestive of a beneficial role of the seed extract. The possible mechanisms of action are discussed.

    • Author Affiliations


      V P Dixit1 S C Joshi1 Prabha Jain1

      1. Reproduction Physiology Section, Department of Zoology, University of Rajasthan, Jaipur - 302 004, India
    • Dates

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