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    • Effects of piretanide on plasma fibrinolytic activity, platelet aggregation and platelet factor-4 release in man

      I S Chohan

      Volume 10 Issue 2 June 1986 pp 243-249

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/010/02/0243-0249

    • Keywords

       

      Piretanide; synthetic fibrinolytic agent; anti-platelet agent; PF-4 release; diuretic

    • Abstract

       

      Piretanide, 4-phenoxy-3-(pyrrolidinyl)-5-sulphamoyl benzoic acid, apart from being an efficient diuretic, enhances endogenous plasma fibrinolytic activity after a single dose of 6 mg administered by oral route. After ingestion of the drug, acceleration of fibrinolytic acitivity became manifest within 1 h, reached its peak in 3 h and was associated with a fall in fibrinogen and diminished urokinase excretion. Piretanide did not cause lysis of fibrinin vitro. Primary platelet aggregation, induced by adenosine-diphosphate, was inhibited by piretanide. Inin vitro experiments piretanide led to effective inhibition of adenosine-diphosphate-induced platelet aggregation with complete inhibition at 5 mM concentration. Piretanide led to a highly significant decrease of platelet factor-4 release.

    • Author Affiliations

       

      I S Chohan1

      1. Department of Biochemistry, Medical Research Centre and Hospital of Ch. Aishi Ram Batra Public Charitable Trust, 1, Tughlakabad Institutional Area, Mehrauli-Badarpur Road, New Delhi - 110 062, India

    • Dates

       
      Published
      June 1986
      Manuscript received
      18 March 1985
      Manuscript revised
      16 April 1986

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