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    • Keywords


      Acid lipase; alkaline lipase; hormone sensitive lipase; lipoprotein lipase; mandur bhasma; liver; kidney; adipose tissue; CCl4

    • Abstract


      ‘Mandur bhasma’, an ayurvedic preparation of iron is used in traditional medicine against hepatitis. In the present study the hepatoprotective property of this drug was tested in albino rats during CC14 induced hepatic injury. The effect of mandur bhasma on the activities of the lipolytic enzymes of rat liver, kidney and adipose tissue were studied during hepatitis induced by CCl4. The activities of acid lipase, alkaline lipase, lipoprotein lipase and hormone sensitive lipase exhibited significant alterations during CCl4 induced hepatic injury, indicating a role for these enzymes in the mobilization of fat from adipose tissue and accumulation of fat in liver and kidney. Simultaneous treatment with mandur bhasma prevented the paraffin mediated and CC14 mediated changes in the enzyme activities. These results suggest the hepatoprotective role of mandur bhasma during CCl4 induced hepatic injury.

    • Author Affiliations


      Pratibha Devarshi1 Aruna Kanase1 Ravindra Kanase1 Sadashiv Mane1 Subhash Patil1 A T Varute1

      1. Cell Biology Section, Zoology Department, Shivaji University, Kolhapur - 416004, India
    • Dates

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