• Antifertility effect of tamoxifen as tested in the female bonnet monkey (Macaca radiata)

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    • Keywords

       

      Antiestrogen; implantation; pregnancy; primate; post-coital contraception

    • Abstract

       

      The administration of a potent antiestrogen, tamoxifen at a dose of 3 mg/kg body weight/day orally post-coitally to cycling mated bonnet monkeys(Macaca radiata) from days 18–30 of cycle resulted in inhibition of establishment of pregnancy in 9 out of 10 monkeys. Tamoxifen effect was not due to interference with luteal function. The effect was specific to tamoxifen as exogenously administered progesterone could not reverse it. In addition to suggesting a role for estrogen in maintenance of early pregnancy in the primate the present study could be a prelude to the development of an effective post-ovulatory approach for regulation of fertility in the human female

    • Author Affiliations

       

      N Ravindranath1 N R Moudgal1

      1. Department of Biochemistry, Center for Advanced Research in Reproductive Biology, Indian Institute of Science, Bangalore - 560 012, India
    • Dates

       
  • Journal of Biosciences | News

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