Changes in the subcellular distribution of brain and heart hexokinase isoenzymes during alloxan diabetes
Gurcharan Kaur Rameshwar Singh Najma Zaheer Baquer
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Changes in the subcellular distribution of hexokinase activity from three brain regions and heart were studied during alloxan induced diabetes. There was an overall decrease in the particulate hexokinase with an increase in the soluble form, after different time intervals of the onset of diabetes. Administration of insulin to the diabetic rats showed a partial counteraction of the enzyme changes. A possible regulation of brain hexokinase by metabolite changes is proposed
Gurcharan Kaur1 Rameshwar Singh1 Najma Zaheer Baquer1
Volume 48, 2023
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