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    • Keywords


      Unilamellar liposomes; dextran conjugate; drug delivery

    • Abstract


      Dextran was covalently coupled to neutral unilamellar liposomes. Dextran conjugated liposomes were cleared from the circulation at a much slower rate than unconjugated liposomes. The uptake of dextran conjugated liposomes by liver and spleen was also decreased. The amount of dextran on the surface of liposomes was found to be a determining factor for their stability in circulation. Dextran conjugated liposomes therefore may be a more effective way of controlled drug release

    • Author Affiliations


      D Pain1 2 P K Das1 3 P Ghosh1 4 B K Bachhawat1

      1. Indian Institute of Chemical Biology, Calcutta - 700 032, India
      2. Laboratory of Cell Biology, The Rockefeller University, New York, New York - 10021, USA
      3. Developmental and Metabolic Neurology Branch, National Institutes of Health, Bethesda, MD - 20205, USA
      4. Department of Microbiology, Uniformed Services University Health Sciences, Bethesda, MD - 20814, USA
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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