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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/006/05/0757-0770

    • Keywords

       

      tRNA; methyltransferases; methylation base modification; function

    • Abstract

       

      Transfer RNA is uniquely enriched with modified bases. A large body of information has accumulated about the occurrence, nature and distribution of modified bases in tRNA. But similar investigations on the enzymes involved in this post-transcriptional modification have been hampered by the instability of the enzymes and lack of suitable substrates. The present review summarises briefly, the occurrence and methods of detection of modified bases, the enzymes involved in their formation and also certain suggestive evidence for the role of modification in cellular metabolism.

    • Author Affiliations

       

      Vani Brahmachari1 T Ramakrishnan1

      1. Microbiology and Cell Biology Laboratory, Indian Institute of Science, Bangalore - 560 012, India
    • Dates

       
  • Journal of Biosciences | News

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