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      https://www.ias.ac.in/article/fulltext/jbsc/006/05/0729-0738

    • Keywords

       

      Compositae; parthenin; sesquiterpene lactone; LD50; toxicity; organelle drug distribution

    • Abstract

       

      Fractionation of methanolic extracts of air dried aerial parts ofParthenium resulted in the isolation of a toxic constituent which was identified as parthenin, the major sesquiterpene lactone from the weed. The LD50 (minimal lethal dose required to cause 50% mortality) for parthenin in rats was 42 mg/kg body weight. When [3H]-parthenin was given orally or by intravenous administration, radioactivity appeared in the milk of lactating laboratory and dairy animals. Tissue distribution of radioactivity revealed that maximum label was detectable in kidneys.

    • Author Affiliations

       

      T R Narasimhan1 B S Keshava Murthy1 N Harindranath1 P V Subba Rao1 2

      1. Institute for Animal Health and Veterinary Biologicals, Bangalore - 560 024, India
      2. Department of Biochemistry, Indian Institute of Science, Bangalore - 560 012, India
    • Dates

       
  • Journal of Biosciences | News

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