• Monoclonal antibodies againstWuchereria bancrofti microfilarial excretory-secretory antigens

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      https://www.ias.ac.in/article/fulltext/jbsc/006/05/0717-0722

    • Keywords

       

      Wuchereria bancrofti ; excretory-secretory antigens; monoclonal antibodies; enzyme linked immunosorbent assay

    • Abstract

       

      A battery of monoclonal antibodies were produced againstWuchereria bancrofti microfilarial excretory-secretory antigens and their specificity was studied using different filarial antigens. Among the 1116 wells plated out, 42 % of the wells developed hybrids and 5 % of the hybrids showed antiWuchereria bancrofti microfilarial excretory-secretory antigens. Specificity studies on the antibodies produced from 63 cloned and expanded hybrids showed 10 clones which were specifically positive only toWuchereria bancrofti microfilarial excretory-secretory antigens.

    • Author Affiliations

       

      M V R Reddy1 W F Piessens1 2 B C Harinath1

      1. Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra - 442 102, India
      2. Department of Tropical Public Health, Harvard School of Public Health, 665, Huntington Avenue, Boston, Massachusetts - 02115, USA
    • Dates

       
  • Journal of Biosciences | News

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