• Studies on the conformations of sialyloligosaccharides and implications

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      https://www.ias.ac.in/article/fulltext/jbsc/006/05/0625-0634

    • Keywords

       

      Conformation; N-acetylneuraminic acid; neuraminidases; sialic acid; sialyloligosaccharides

    • Abstract

       

      Theoretical investigations, using semi-empirical potential functions have been carried out to predict the favoured conformations of the terminal dissaccharide fragments of various sialyloligosaccharides. The proposed conformational similarity for these fragments has been correlated to the binding specificity of neuraminidases. These calculations predict that bacterial neuraminidases have a binding site which can accommodate only two sugar residues and virus neuraminidases have a binding site which can accommodate more than two sugar residues.

    • Author Affiliations

       

      K Veluraja1 V S R Rao1

      1. Molecular Biophysics Unit, Indian Institute of Science, Bangalore - 560012, India
    • Dates

       
  • Journal of Biosciences | News

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