• Excretion of pyruvate in nickel toxicity in wild type and Ni2+ resistant mutants ofNeurospora crassa

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    • Keywords


      Neurospora crassa ; nickel-resistantN. crassa; nickel toxicity; pyruvate excretion

    • Abstract


      The parent wild strainNeurospora crassa Em 5297a and three Ni2+ resistantNeurospora crassa mutants have been shown to excrete pyruvate into the culture medium in Ni2+ and Co2+ toxicities. Ni2+ has a more pronounced effect in this regard. The excretion is progressive with growth inhibition and is abolished by Mg2+ in all strains and by Fe3+ partially in the Em strain but not inNeurospora crassa NiR1. Pyruvate, citrate and malate supplementation reverse growth inhibition caused by excess Ni2+, but with concomitant suppression of Ni2+ accumulation. It is suggested that one of the features of Ni2+ toxicity inNeurospora crassa is a derangement in carbohydrate metabolism at step(s) beyond pyruvate and that this is possibly due to decreased invivo activity of Mg2+ dependent processes

    • Author Affiliations


      P Maruthi Mohan1 2 K Sivarama Sastry1

      1. Department of Biochemistry, Osmania University, Hyderabad - 500 007, India
      2. Department of Biochemistry, Indian Institute of Science, Bangalore - 560 012, India
    • Dates

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