• Evaluation of fractionatedWuchereria bancrofti microfilarial excretory-secretory antigens for diagnosis of bancroftian filariasis by enzyme linked immunosorbent assay

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    • Keywords

       

      Microfilarial excretory-secretory antigen; ultramembrane filtration; enzyme linked immunosorbent assay

    • Abstract

       

      TheWuchereria bancrofti microfilarial excretory-secretory antigens were fractionated into ES1, ES2, ES3 and ES4 by ultra-membrane filtration and evaluated for their diagnostic utility by enzyme linked immunosorbent assay. Three of the four fractions showed antigenic activity (ES2, ES3 and ES4). The antigen fractions ES2 and ES4 were highly active in the detection of filarial IgM antibody in clinical filariasis and microfilaraemia respectively. The chemical characterization of the ES2 and ES4 antigen fractions showed that they were glycoproteins

    • Author Affiliations

       

      M V R Reddy1 Ashok Malhotra1 G B K S Prasad1 B C Harinath1

      1. Department of Biochemistry, M. G. Institute of Medical Sciences, Sevagram, Wardha - 442 102, India
    • Dates

       
  • Journal of Biosciences | News

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