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    • Lipoic acid and diabetes: Effect of dihydrolipoic acid administration in diabetic rats and rabbits

      C V Natraj V M Gandhi K K G Menon

      Volume 6 Issue 1 March 1984 pp 37-46

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/006/01/0037-0046

    • Keywords

       

      α-Lipoic acid; dihydrolipoic acid; gas chromatography; alloxan diabetic rats; blood glucose; acetoacetate; liver glycogen; fat synthesis

    • Abstract

       

      Relative α-lipoic acid content of diabetic livers was considerably less than that of normal livers as determined by gas chromatography. It was not possible to detect any dihydrolipoic acid in the livers. Biochemical abnormalities such as hyperglycaemia, ketonemia, reduction in liver glycogen and impaired incorporation of [2-14C] -acetate into fatty acids in alloxan diabetic rats were brought to near normal levels by the oral or intraperitoneal administration of dihydrolipoic acid. The effect of α-lipoic acid was comparable to that of dihydrolipoic acid in reducing the blood sugar levels of diabetic rabbits during a glucose tolerance test.

      The results suggest that the mode of action of lipoic acid was through stimulation of pyruvate dehydrogenase.

    • Author Affiliations

       

      C V Natraj1 V M Gandhi1 K K G Menon1

      1. Hindustan Lever Research Centre, Andheri, Bombay - 400099, India

    • Dates

       
      Published
      March 1984
      Manuscript received
      17 November 1983
      Manuscript revised
      3 February 1984

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      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


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