• Biological characteristics of a factor suppressing follicle stimulating hormone (inhibin) from ovine testes

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    • Keywords


      Regulation of FSH; testicular function; gonadotropin

    • Abstract


      Inhibin (follicle stimulating hormone suppressing factor) isolated from ovine testes has been characterized for its biological activity using a variety of tests. The bioassay used — inhibition of the human chorionic gonadotropin induced increment in the mouse uterine weight-demonstrates that there is a significant increment in specific activity (approx. 300-fold) with the progress of purification. Eventhough the final product has not been obtained in a homogenous state it has been possible to show that(a) [125I]-labelled inhibin is preferentially taken up and retained by the pituitary, pretreatment of rats with testosterone facilitating this uptake;(b) it is able to suppress specifically the levels of follicle stimulating hormone in castrated as well as immature intact rats and (c) treatment of immature male rats with inhibin preparation for ten days results in impairment of testicular function as judged by3H-thymidine incorporation into testicular DNA and testicular hyaluronidase activity.

    • Author Affiliations


      H M Shashidhara Murthy1 2 N R Moudgal1

      1. Laboratory of Endocrine Biochemistry, Centre for Advanced Study in Reproductive Biology (ICMR), Indian Institute of Science, Bangalore - 560 012
      2. Hormone Research Laboratory, University of California Medical School, San Francisco, CA - 94143, USA
    • Dates

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