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    • Inhibition of avian myeloblastosis virus reverse transcriptase by an RNA-binding protein from plasma membranes of normal and tumor cells

      Veena K Parnaik Pramod K Srivastava M R Das

      Volume 5 Issue 2 June 1983 pp 107-114

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/005/02/0107-0114

    • Keywords

       

      Reverse transcriptase; RNA-binding protein; plasma membranes

    • Abstract

       

      Purified plasma membranes from normal rat liver, a rat hepatoma and a rat hepatic fibrosarcoma have been shown to contain a protein which drastically inhibits avian myeloblastosis virus reverse transcriptase activity. The inhibition is caused by the binding of the protein to the template. The binding and the consequent inhibition of enzyme activity are template-specific; copying of RNA templates is inhibited whilst that of DNA templates remains unaffected. Investigations using different templates suggest that the inhibitory protein has a stronger binding affinity for G, C-rich templates. The inhibitor appears to have a wide distribution in plasma membranes from diverse sources.

    • Author Affiliations

       

      Veena K Parnaik1 Pramod K Srivastava1 M R Das1

      1. Regional Research Laboratory, Centre for Cellular and Molecular Biology, Hyderabad - 500 009

    • Dates

       
      Published
      June 1983
      Manuscript received
      29 November 1982
      Manuscript revised
      26 April 1983

  • Journal of Biosciences | News

      Forthcoming Special issue.


    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

      Posted on April 12, 2023
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