• Reactivity of fluorodinitrobenzene with intact human leucocytes: Examination of sites of action and the molecular entities involved in interaction

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    • Keywords

       

      Dinitrophenylated leucocytes; leukaemia-associated antigenicity; hydrophylic-hydrophobic interconversions; dinitrophenylated-epsilon lysine; dinitrophenylated phosphatidyl ethanolamine; dinitrophenylated-phosphatidyl serine

    • Abstract

       

      The epsilon amino groups of lysine and to a lesser extent amino groups on phosphotidyl ethanolamine and phosphotidyl serine situated on cell membranes of normal human leucocytes have been identified as the sites of dinitrophenylation.In situ conversion of 10,000 hydrophylic amino sites into hydrophobic sites on cell surfaces causes conformational changes in cell membranes with exposures of leukaemic cell-specific neo-antigens on tagged cell surfaces.

    • Author Affiliations

       

      S S Joshi1 2 3 V S Basrur1 M B Sahasrabudhe1 2

      1. Cancer Research Institute, Tata Memorial Centre, Parel, Bombay - 400 012
      2. 41, Saras Baug, Sion-Trombay Road, Deonar, Bombay - 400 088
      3. Indiana University School of Medicine, Gary, Indiana - 46408, USA
    • Dates

       
  • Journal of Biosciences | News

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