• Cholesterol metobolism of macrophages in relation to the presence ofMycobacterium leprae

    • Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/004/03/0307-0316

    • Keywords

       

      Mycobacterium ; cholesterol; cholesterol ester level; macrophage

    • Abstract

       

      Macrophages phagocytoseMycobacterium leprae and live bacilli inside such macrophages alter the lipid metabolism. There is increased accumulation of cholesterol ester in the bacteria infected cells. This increase appears to be due to the decreased level of esterase enzyme that could hydrolyse cholesterol esters. Associated with decreased level of this enzyme is the reduced amount of protein synthesis. Increased cholesterol ester may be responsible for conversion of macrophages into foamy cells in the presence ofM. leprae.

    • Author Affiliations

       

      Ishwarig G Kurup1 P R Mahadevan1

      1. The Foundation for Medical Research, 84-A, R. G. Thadani Marg, Worli, Bombay - 400 018
    • Dates

       
  • Journal of Biosciences | News

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2017-2019 Indian Academy of Sciences, Bengaluru.