Activity of fructose-1,6-bisphosphatase (EC 18.104.22.168), one of the key gluconeogenic enzymes, was measured in human fetal brain and liver during development. Fructose-1,6-bisphosphatase was distributed throughout the different regions of the brain. In contrast to the partially purified enzyme from the brain, the liver enzyme was dependent on Mg2+ for maximal activity, EDTA, citrate, oleate and linoleate were stimulatory, whereas 5′-AMP inhibited the activity of the liver enzyme.
Volume 45, 2020
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