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    • Keywords


      Ionen-oligomers; DNA; melting temperature; circular dichroism; exciton splitting

    • Abstract


      A novel polycationic ionen was synthesized and fractionated on carboxymethyl-Sephadex using a salt gradient in 7M urea. A series of oligomers of discrete length were characterised by ultraviolet spectra. The ultraviolet spectra of oligomers revealed a new band centred at 232.5 nm which was probably due to exciton splitting. Thermal denaturation studies indicated both stabilization of the helix conformation and a higher degree of cooperativity in the melting of DNA (oligomers)n complex as compared to native calf thymus DNA. Ionen oligomers exhibited large extrinsic Cotton effect at 232.5 nm which could be attributed to exciton interaction.

    • Author Affiliations


      V H Mulimani1 A C Roth1 2 R A Day1 2

      1. Department of Chemistry, Division of Biochemistry, Karnatak University, Dharwad - 580 003
      2. Department of Chemistry, University of Cincinnati, Cincinnati, Ohio - 45221, USA
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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