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    • Keywords


      Benzanthrone; dye intermediate; uptake by the skin; serum transport

    • Abstract


      The uptake of benzanthrone by rat skin showed saturation kinetics and was dependent upon the weight of skin and time, temperature and pH of the incubation medium. Heating of segments above 50‡C caused significant lowering of the uptake. The uptake was irreversibly inhibited by HgCl2 and not by sodium arsenate, KCN, NaF,p-chloromercuriben zoate, N-ethyl-maleimide, cycloheximide, iodoacetic acid and 2,4-dinitrophenol suggesting that the uptake was not energy-dependent. Lipid micelles of the skin accounted for a part of the binding. Most of the benzanthrone taken up by the skin was effluxed through serum proteins.

    • Author Affiliations


      A Joshi1 S K Khanna1 G B Singh1 C R Krishna Murti1

      1. Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow - 226 001
    • Dates

  • Journal of Biosciences | News

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