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    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/003/02/0191-0196

    • Keywords

       

      β-thalassaemia; haemoglobin E; haemoglobin A

    • Abstract

       

      The distribution patterns of different haemoglobins were observed amongst the family members of β-thalassaemia homozygous and HbE-β-thalassaemia patients with the aid of gel electrophoretic and alkali denaturation techniques. Of the 18 families studied, four belonged to β-thalassaemia homozygous and 14 to HbE-β-thalassaemia patients. Interaction of HbE and β-thalassaemia genes resulted in major clinical abnormalities with increase in the percentages of haemoglobins F and E. The percentages of HbA2 in homozygous β-thalassaemia were within the normal range. Although in Southeast Asia the β° type of HbE-thalassaemia is more prevalent, only one individual with this type of thalassaemia was observed during this survey. In the rest of the patients examined the percentages of adult haemoglobin ranged from 5.2 to 42.5 indicating the presence of a β+ type gene.

    • Author Affiliations

       

      Manju Ajmani1 Geeta Talukder1 Archana Sharma1 D K Bhattacharya1 2

      1. Human Genetics Unit, Centre for Advanced Studies in Cell & Chromosome Research, Department of Botany, University of Calcutta, 35, Ballygunj Circular Road, Calcutta - 700 019
      2. Department of Pathology, North Bengal University, Siliguri - 734 430

    • Dates

       
      Published
      June 1981
      Manuscript received
      24 May 1980
      Manuscript revised
      14 November 1980

  • Journal of Biosciences | News

      Forthcoming Special issue.


    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

      Posted on April 12, 2023
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    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

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