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    • Keywords


      Hexokinase isoenzymes; alloxan diabetes; insulin; cytosol; total particulate fraction

    • Abstract


      Hexokinase is present in the tissues in four isoenzymic forms. Cerebral tissue contains predominantly Type I hexokinase which is believed to be insulin-insensitive. In cerebral tissue about 60 to 70% of the hexokinase is bound to the particulate fraction. The changes in the distribution of hexokinase Type I and Type II together with the bound and free hexokinase have been studied in control, diabetic and diabetic animals treated with insulin. The results indicate that the presence of insulin is essential for the normal binding of the hexokinase to the particulate fraction. In heart tissue, Type II hexokinase bound to the pellet shows a significant decrease in diabetes, which is reversed on insulin administration.

    • Author Affiliations


      F Ali1 A S N Murthy1 N Z Baquer1

      1. School of Life Sciences, Jawaharlal Nehru University, New Mehrauli Road, New Delhi - 110 067
    • Dates

  • Journal of Biosciences | News

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      Posted on July 25, 2019

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