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    • Keywords


      Bilirubin catabolism; photodegradation; superoxide anion; singlet oxygen

    • Abstract


      The photodecomposition of bilirubin follows first order kinetics with akB value of 12.5 × 10-3 min-1. In the presence of a model system generating superoxide anions, such as xanthine-xanthine oxidase, thekB value was 103 × 10-3 min-1 This ten-fold enhancement ofkB value by xanthine-xanthine oxidase was abolished when the reaction mixture was supplemented with a superoxide ion scavenger— superoxide dismustase. Further, known singlet oxygen quenchers like Β-carotene and bistidine did not prevent the enhancement of bilirubin oxidation by xanthine-xanthine oxidase, thereby ruling out the obligatory conversion of Superoxide anion to singlet oxygen. It is concluded that radical oxygen mediated bilirubin degradation might be a natural catabolic route for the bile pigment degradation during oxygen stress.

    • Author Affiliations


      Ravi Kaul1 Hari K Kaul1 Prakash C Bajpai1 C R Krishna Murti2

      1. Department of Pediatrics, K.G. Medical College, Lucknow
      2. Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Post Box No. 88, Lucknow - 226 001
    • Dates

  • Journal of Biosciences | News

      Forthcoming Special issue.

    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".

      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.

      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.

      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

      Posted on April 12, 2023
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      Posted on July 25, 2019

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