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    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jbsc/001/04/0369-0375

    • Keywords

       

      cAMP; adenosine; fatty acid synthesis; chicken liver; adenosine deaminase

    • Abstract

       

      The biosynthesis of fatty acids from [l-14C]-acetate in the chicken liver slicesin vitro was inhibited by cAMP, adenosine, 5′-AMP, 3′-AMP, ATP, NAD and FAD but not by adenine, guanine or inosine. The minimum structural requirement for inhibition appears to be adenosine. The inhibitory action of adenosine, 5′-AMP and NAD on fatty acid synthesis is likely to be mediated by adenosine or its metabolites since adenosine deaminase reverses the inhibition while it has no effect on the inhibition by cAMP; thus, the inhibitory effect of cAMP is probably not mediated through its hydrolysis products, 5′-AMP, or adenosine.

    • Author Affiliations

       

      N R Bhat1 G R Kulkarni1 A Madhava Rao1 S K Murthy1

      1. Department of Biochemistry, Indian Institute of Science, Bangalore - 560 012

    • Dates

       
      Published
      December 1979
      Manuscript received
      7 February 1979
      Manuscript revised
      14 August 1979

  • Journal of Biosciences | News

      Forthcoming Special issue.


    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

      Posted on April 12, 2023
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    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

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