Beryllium toxicity inNeurospora crassa
A Naidu J Nirmala K Sivarama Sastry
Click here to view fulltext PDF
Permanent link:
https://www.ias.ac.in/article/fulltext/jbsc/001/03/0279-0287
InNeurospora crassa,0.44 mM Be2+ caused half-maximal inhibition of growth and this inhibition could be fully counteracted by the addition of 2.5 mM Ca2+ to the medium. Mn2+ and Mg2+ were less effective in reversing the growth inhibition caused by Be2+ and the order of effectiveness was Ca2+ > Mn2+ > Mg2+. Fe3+ and Zn2+ were ineffective in reversing Be2+ toxicity.
Pyruvate, malate and succinate also reversed the growth inhibition caused by Be2+ inN. crassa. Pyruvate restored growth by a mechanism not involving control of Be2+ accumulation in the mould. The rate of utilisation of glucose by the mycelia grown in the presence of Be2+ was reduced, while that of pyruvate was not affected. The results indicate that the primary metabolic lesion in Be2+ toxicity inN. crassa is probably a block at some step(s) in the glycolytic sequence.
A Naidu1 J Nirmala1 K Sivarama Sastry1
Volume 48, 2023
All articles
Continuous Article Publishing mode
Click here for Editorial Note on CAP Mode
© 2023-2024 Indian Academy of Sciences, Bengaluru.